CAMPEONATO DE APERTURA 2022 |
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| 1º Fecha | ||||
| 4-feb-2022 | Asuncion | Sol de America | 0 | |
| Nacional | 0 | |||
| 4-feb-2022 | Asuncion | Olimpia | 2 | Paiva, Gonzalez |
| General Caballero | 2 | Romero, Mirabel | ||
| 5-feb-2022 | Asuncion | Resistencia | 1 | Brizuela |
| Tacuary | 0 | |||
| 5-feb-2022 | Itaugua | 12 de Octubre | 1 | Melgarejo (A) |
| Libertad | 6 | Melgarejo, Enciso (3), Santa Cruz, Barboza | ||
| 6-feb-2022 | Villarrica | Guaireña | 0 | |
| Guarani | 0 | |||
| 6-feb-2022 | Asuncion | Cerro Porteño | 3 | Gimenez, Morales, Aquino |
| Sportivo Ameliano | 2 | Caceres, Barreto | ||
| 2º Fecha | ||||
| 11-feb-2022 | Asuncion | Tacuary | 1 | Valdez |
| 12 de Octubre | 1 | Roa | ||
| 11-feb-2022 | Asuncion | Sportivo Ameliano | 1 | Vargas |
| Resistencia | 4 | J. Gonzalez, Paniagua, Palacios (P), A. Gonzalez | ||
| 12-feb-2022 | Villarrica | Guaireña | 1 | Duarte |
| Olimpia | 3 | Paiva (2), Silva | ||
| 12-feb-2022 | Asuncion | Libertad | 1 | Enciso (P) |
| General Caballero | 0 | |||
| 13-feb-2022 | Asuncion | Guarani | 0 | |
| Sol de America | 1 | Cazal | ||
| 13-feb-2022 | Asuncion | Nacional | 2 | Fleitas, Santacruz |
| Cerro Porteño | 3 | Diaz, Oviedo (2) | ||
| 3º Fecha | ||||
| 18-feb-2022 | Itaugua | 12 de Octubre | 2 | Gonzalez (2, 1P) |
| Sportivo Ameliano | 1 | Sanguina | ||
| 18-feb-2022 | Asuncion | Resistencia | 3 | Palacios, D. Martinez, F. Martinez |
| Nacional | 1 | Bruera | ||
| 19-feb-2022 | Asuncion | Cerro Porteño | 2 | Oviedo, Morales |
| Guarani | 0 | |||
| 19-feb-2022 | Ciudad del Este | General Caballero | 2 | Salcedo (2) |
| Tacuary | 0 | |||
| 20-feb-2022 | Asuncion | Sol de America | 1 | Verdun |
| Guaireña | 0 | |||
| 20-feb-2022 | Asuncion | Olimpia | 2 | Silva (P), Paiva |
| Libertad | 2 | Viera, Melgarejo | ||
| 4º Fecha | ||||
| 25-feb-2022 | Asuncion | Sportivo Ameliano | 1 | Caceres |
| General Caballero | 0 | |||
| 25-feb-2022 | Asuncion | Nacional | 2 | Fleitas, Santacruz |
| 12 de Octubre | 2 | Doldan, Roa | ||
| 26-feb-2022 | Asuncion | Guarani | 3 | Bareiro, Samudio, Gonzalez |
| Resistencia | 3 | Martinez, Gonzalez (A), Ruiz Diaz | ||
| 27-feb-2022 | Villarrica | Guaireña | 0 | |
| Cerro Porteño | 2 | Morales (2) | ||
| 27-feb-2022 | Asuncion | Tacuary | 0 | |
| Libertad | 1 | Enciso | ||
| 26-mar-2022 | Asuncion | Sol de America | 0 | |
| Olimpia | 1 | Gonzalez | ||
| 5º Fecha | ||||
| 4-mar-2022 | Ciudad del Este | General Caballero | 1 | Hauche |
| Nacional | 2 | Bruera, Prieto | ||
| 5-mar-2022 | Asuncion | Resistencia | 2 | D. Martinez, R. Martinez (P) |
| Guaireña | 2 | Salinas, Murillo | ||
| 5-mar-2022 | Asuncion | Cerro Porteño | 4 | Morales (2), Aquino (P), Espinola |
| Sol de America | 0 | |||
| 6-mar-2022 | Asuncion | Libertad | 2 | Villalba, Enciso |
| Sportivo Ameliano | 0 | |||
| 6-mar-2022 | Asuncion | Olimpia | 2 | Quintana, Camacho |
| Tacuary | 0 | |||
| 7-mar-2022 | Itaugua | 12 de Octubre | 1 | Ortigoza (P) |
| Guarani | 3 | Fernandez (P), Mendoza, Segovia (P) | ||
| 6º Fecha | ||||
| 11-mar-2022 | Asuncion | Sportivo Ameliano | 0 | |
| Tacuary | 2 | Ocampos, Fernandez | ||
| 12-mar-2022 | Asuncion | Sol de America | 1 | Duffard (A) |
| Resistencia | 1 | Jacquet (A) | ||
| 12-mar-2022 | Asuncion | Guarani | 3 | Fernandez (3, 1P) |
| General Caballero | 1 | Salcedo (P) | ||
| 13-mar-2022 | Asuncion | Cerro Porteño | 0 | |
| Olimpia | 2 | Silva, Gonzalez | ||
| 14-mar-2022 | Villarrica | Guaireña | 0 | |
| 12 de Octubre | 0 | |||
| 14-mar-2022 | Asuncion | Nacional | 0 | |
| Libertad | 3 | Riveros, Santa Cruz, Cardozo | ||
| 7º Fecha | ||||
| 19-mar-2022 | Itaugua | 12 de Octubre | 0 | |
| Sol de America | 1 | Viera (P) | ||
| 19-mar-2022 | Asuncion | Resistencia | 0 | |
| Cerro Porteño | 3 | Morales (2), Aquino | ||
| 20-mar-2022 | Asuncion | Libertad | 2 | Cardozo, Enciso |
| Guarani | 0 | |||
| 20-mar-2022 | Asuncion | Olimpia | 0 | |
| Sportivo Ameliano | 2 | Caballero, Oviedo | ||
| 21-mar-2022 | Asuncion | Tacuary | 2 | Sanabria (2, 1P) |
| Nacional | 1 | Fleitas | ||
| 21-mar-2022 | Ciudad del Este | General Caballero | 0 | |
| Guaireña | 1 | Godoy (P) | ||
| 8º Fecha | ||||
| 1-abr-2022 | Asuncion | Cerro Porteño | 2 | Galeano, Romero |
| 12 de Octubre | 0 | |||
| 1-abr-2022 | Asuncion | Resistencia | 2 | Martinez, Araujo |
| Olimpia | 1 | Paiva | ||
| 2-abr-2022 | Villarrica | Guaireña | 2 | Gimenez, Salinas |
| Libertad | 3 | Enciso (2), Santacruz (A) | ||
| 2-abr-2022 | Asuncion | Sol de America | 2 | Ozuna, Aguilar |
| General Caballero | 3 | Gonzalez (2), Marabel | ||
| 3-abr-2022 | Asuncion | Nacional | 2 | Bruera (2) |
| Sportivo Ameliano | 1 | Arce | ||
| 3-abr-2022 | Asuncion | Guarani | 1 | Colman |
| Tacuary | 2 | Fernandez, Valdez | ||
| 9º Fecha | ||||
| 8-abr-2022 | Itaugua | 12 de Octubre | 1 | Doldan |
| Resistencia | 1 | Martinez (P) | ||
| 8-abr-2022 | Asuncion | Olimpia | 1 | Gonzalez |
| Nacional | 2 | Bruera (2) | ||
| 9-abr-2022 | Ciudad del Este | General Caballero | 0 | |
| Cerro Porteño | 0 | |||
| 9-abr-2022 | Asuncion | Sportivo Ameliano | 0 | |
| Guarani | 1 | Ferreira | ||
| 10-abr-2022 | Asuncion | Libertad | 3 | Villalba, Mendieta, Enciso |
| Sol de America | 1 | Benegas | ||
| 10-abr-2022 | Asuncion | Tacuary | 0 | |
| Guaireña | 1 | Duarte | ||
| 10º Fecha | ||||
| 16-abr-2022 | Itaugua | 12 de Octubre | 0 | |
| Olimpia | 0 | |||
| 16-abr-2022 | Asuncion | Guarani | 0 | |
| Nacional | 1 | Bruera (P) | ||
| 17-abr-2022 | Villarrica | Guaireña | 2 | Godoy (P), Barrios |
| Sportivo Ameliano | 1 | Oviedo | ||
| 17-abr-2022 | Asuncion | Cerro Porteño | 4 | Aquino, Diaz, Roloon, Martins |
| Libertad | 0 | |||
| 17-abr-2022 | Asuncion | Resistencia | 2 | Ruiz Diaz, Martinez |
| General Caballero | 1 | Barreto | ||
| 18-abr-2022 | Asuncion | Sol de America | 1 | Rojas |
| Tacuary | 0 | |||
| 11º Fecha | ||||
| 19-abr-2022 | Asuncion | Olimpia | 1 | Recalde |
| Guarani | 0 | |||
| 20-abr-2022 | Asuncion | Nacional | 3 | Arrua, Prieto, Franco |
| Guaireña | 1 | Otazu (P) | ||
| 20-abr-2022 | Ciudad del Este | General Caballero | 0 | |
| 12 de Octubre | 0 | |||
| 20-abr-2022 | Asuncion | Libertad | 2 | Enciso, Melgarejo |
| Resistencia | 2 | Palacios, Martinez | ||
| 21-abr-2022 | Asuncion | Tacuary | 2 | Valdez, Vera |
| Cerro Porteño | 0 | |||
| 21-abr-2022 | Asuncion | Sportivo Ameliano | 3 | Oviedo, Gaitan (P), Cabrera |
| Sol de America | 1 | Cazal | ||
| 12º Fecha | ||||
| 23-abr-2022 | Asuncion | Libertad | 4 | Villalba, Bogarin, Melgarejo, Davalos (A) |
| 12 de Octubre | 0 | |||
| 23-abr-2022 | Ciudad del Este | General Caballero | 2 | Marabel, Hauche |
| Olimpia | 3 | W. Gonzalez, Paiva, D. Gonzalez | ||
| 24-abr-2022 | Asuncion | Sportivo Ameliano | 0 | |
| Cerro Porteño | 1 | Romero | ||
| 24-abr-2022 | Asuncion | Guarani | 2 | Fernandez (2, 1P) |
| Guaireña | 1 | Godoy | ||
| 25-abr-2022 | Asuncion | Tacuary | 3 | Valdez, Fernandez, Espinoza |
| Resistencia | 1 | Martinez (P) | ||
| 25-abr-2022 | Asuncion | Nacional | 0 | |
| Sol de America | 3 | Nuñez (A), Estigarribia, Rojas | ||
| 13º Fecha | ||||
| 29-abr-2022 | Asuncion | Resistencia | 3 | Bustos (2), Recalde |
| Sportivo Ameliano | 0 | |||
| 29-abr-2022 | Itaugua | 12 de Octubre | 2 | Batallini, Sanabria |
| Tacuary | 0 | |||
| 30-abr-2022 | Ciudad del Este | General Caballero | 0 | |
| Libertad | 1 | Villalba | ||
| 30-abr-2022 | Asuncion | Cerro Porteño | 1 | Delvalle |
| Nacional | 0 | |||
| 1-may-2022 | Asuncion | Sol de America | 2 | Estigarribia, Verdun |
| Guarani | 2 | Fernandez (2) | ||
| 1-may-2022 | Asuncion | Olimpia | 1 | Gonzalez |
| Guaireña | 0 | |||
| 14º Fecha | ||||
| 6-may-2022 | Asuncion | Nacional | 1 | Vera |
| Resistencia | 2 | Martinez (P), Palacios | ||
| 6-may-2022 | Asuncion | Sportivo Ameliano | 2 | Caceres, Sanguina |
| 12 de Octubre | 2 | Chavez, Cabrera (A) | ||
| 7-may-2022 | Asuncion | Tacuary | 0 | |
| General Caballero | 0 | |||
| 7-may-2022 | Asuncion | Libertad | 1 | Santa Cruz |
| Olimpia | 0 | |||
| 8-may-2022 | Villarrica | Guaireña | 2 | Maciel, Ruiz |
| Sol de America | 1 | Verdun | ||
| 8-may-2022 | Asuncion | Guarani | 1 | Caceres |
| Cerro Porteño | 2 | Aquino, Rolon | ||
| 15º Fecha | ||||
| 6-may-2022 | Itaugua | 12 de Octubre | 1 | Batallini (P) |
| Nacional | 2 | Bruera, Santacruz | ||
| 10-may-2022 | Asuncion | General Caballero | 0 | |
| Sportivo Ameliano | 3 | Zeballos, Barreto, Arce | ||
| 10-may-2022 | Asuncion | Libertad | 3 | Mendieta, Espinoza (A), Merlini |
| Tacuary | 0 | |||
| 11-may-2022 | Asuncion | Olimpia | 1 | Gonzalez |
| Sol de America | 0 | |||
| 11-may-2022 | Asuncion | Cerro Porteño | 0 | |
| Guaireña | 0 | |||
| 11-may-2022 | Asuncion | Resistencia | 1 | Brizuela |
| Guarani | 2 | Fernandez, Adorno | ||
| 16º Fecha | ||||
| 13-may-2022 | Asuncion | Nacional | 1 | Bruera |
| General Caballero | 2 | Marabel (P), Hauche | ||
| 14-may-2022 | Asuncion | Guaireña | 0 | |
| Resistencia | 0 | |||
| 14-may-2022 | Asuncion | Sol de America | 2 | Verdun (P), Valdez |
| Cerro Porteño | 1 | Moreno Martins | ||
| 15-may-2022 | Asuncion | Sportivo Ameliano | 1 | Sarquis |
| Libertad | 3 | Santa Cruz (2), Merlini | ||
| 15-may-2022 | Asuncion | Tacuary | 1 | Bareiro |
| Olimpia | 4 | Silva (2, 1P), Gimenez (A), Gonzalez | ||
| 16-may-2022 | Asuncion | Guarani | 3 | Contrera, Fernandez (2) |
| 12 de Octubre | 0 | |||
| 17º Fecha | ||||
| 20-may-2022 | Asuncion | Tacuary | 1 | Ocampos |
| Sportivo Ameliano | 0 | |||
| 21-may-2022 | Asuncion | Resistencia | 0 | |
| Sol de America | 0 | |||
| 21-may-2022 | Ciudad del Este | General Caballero | 0 | |
| Guarani | 4 | Contrera, Gonzalez, Benitez, Fernandez | ||
| 22-may-2022 | Asuncion | Olimpia | 0 | |
| Cerro Porteño | 4 | Oviedo (P), Fariña, Rodriguez (2) | ||
| 22-may-2022 | Asuncion | Libertad | 1 | Santa Cruz |
| Nacional | 0 | |||
| 30-may-2022 | Itaugua | 12 de Octubre | 0 | |
| Guaireña | 4 | Molinas (A), Otazu, Alonso (2, 1P) | ||
| 18º Fecha | ||||
| 12-jun-2022 | Villarrica | Guaireña | 1 | Paniagua |
| General Caballero | 2 | Gonzalez, Hauche | ||
| 12-jun-2022 | Asuncion | Sol de America | 0 | |
| 12 de Octubre | 0 | |||
| 13-jun-2022 | Asuncion | Nacional | 3 | Prieto (2), Bruera |
| Tacuary | 0 | |||
| 13-jun-2022 | Asuncion | Guarani | 1 | Fernandez |
| Libertad | 1 | Santa Cruz | ||
| 14-jun-2022 | Asuncion | Sportivo Ameliano | 1 | Caballero |
| Oiimpia | 4 | Cardozo, Paiva, Quintana, Otalvaro | ||
| 14-jun-2022 | Asuncion | Cerro Porteño | 1 | Fariña |
| Resistencia | 0 | |||
| 19º Fecha | ||||
| 17-jun-2022 | Ciudad del Este | General Caballero | 1 | Marabel |
| Sol de America | 1 | Borja | ||
| 17-jun-2022 | Asuncion | Libertad | 2 | Jimenez (A), Martinez |
| Guaireña | 0 | |||
| 18-jun-2022 | Itaugua | 12 de Octubre | 0 | |
| Cerro Porteño | 1 | Oviedo | ||
| 18-jun-2022 | Asuncion | Sportivo Ameliano | 2 | Sanguina, Arce |
| Nacional | 2 | Bruera (2, 1P) | ||
| 19-jun-2022 | Asuncion | Olimpia | 6 | Paiva, Gonzalez (2), Quintana, Brizuela (A), Torres |
| Resistencia | 1 | Martinez | ||
| 19-jun-2022 | Asuncion | Tacuary | 0 | |
| Guarani | 2 | Contrera, Benitez | ||
| 20º Fecha | ||||
| 21-jun-2022 | Asuncion | Sol de America | 0 | |
| Libertad | 3 | Campuzano, Melgarejo (2) | ||
| 21-jun-2022 | Asuncion | Cerro Porteño | 3 | Oviedo (3) |
| General Caballero | 1 | Vera | ||
| 22-jun-2022 | Asuncion | Resistencia | 0 | |
| 12 de Octubre | 1 | Ortiz | ||
| 22-jun-2022 | Asuncion | Nacional | 1 | Santacruz (P) |
| Olimpia | 1 | Silva | ||
| 23-jun-2022 | Asuncion | Guarani | 1 | Fernandez |
| Sportivo Ameliano | 1 | Sanguina | ||
| 23-jun-2022 | Villarrica | Guaireña | 0 | |
| Tacuary | 0 | |||
| 21º Fecha | ||||
| 25-jun-2022 | Ciudad del este | General Caballero | 2 | Marabel, Franco |
| Resistencia | 1 | Martinez | ||
| 25-jun-2022 | Asuncion | Libertad | 1 | Merlini |
| Cerro Porteño | 0 | |||
| 26-jun-2022 | Asuncion | Olimpia | 4 | Gonzalez, Recalde, Silva, Camacho (P) |
| 12 de Octubre | 1 | Roa | ||
| 26-jun-2022 | Asuncion | Nacional | 0 | |
| Guarani | 1 | Caceres | ||
| 27-jun-2022 | Asuncion | Sportivo Ameliano | 2 | Oviedo, Zeballos |
| Guaireña | 2 | Villagra, Murillo | ||
| 27-jun-2022 | Asuncion | Tacuary | 2 | Valdez, Gonzalez |
| Sol de America | 2 | Borja, Verdun | ||
| 22º Fecha | ||||
| 1-jul-2022 | Villarrica | Guaireña | 1 | Otazu |
| Nacional | 1 | Nuñez | ||
| 1-jul-2022 | Asuncion | Sol de America | 0 | |
| Sportivo Ameliano | 1 | Sarquis | ||
| 2-jul-2022 | Asuncion | Cerro Porteño | 1 | Gimenez (A) |
| Tacuary | 0 | |||
| 2-jul-2022 | Asuncion | Resistencia | 0 | |
| Libertad | 4 | Cardozo (2), Mendieta, Alcaraz | ||
| 3-jul-2022 | Itaugua | 12 de Octubre | 1 | Vera |
| General Caballero | 3 | Marabel (2), Bordon | ||
| 3-jul-2022 | Asuncion | Guarani | 0 | |
| Olimpia | 2 | Camacho, Gonzalez | ||